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This 1976 transmission electron microscopic (TEM) image depicted a brain capillary of a mouse that had been experimentally infected with Orientia tsutsugamushi rickettsial micro-organisms. Revealed, was the presence of pericapillary hemorrhage and edema. Several of the O. tsutsugamushi organisms were visible within the cytoplasm of a degenerating capillary endothelial cell. Formerly known as Rickettsia tsutsugamushi, O. tsutsugamushi is the pathogen responsible for causing the febrile disease known as scrub typhus. The disease is transmitted to humans through the bite of larval trombiculid mites, i.e., chiggers, that had fed on infected rodents.
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