This photomicrograph revealed the cytoarchitectural histopathologic changes detected in a kidney sample taken from a Marburg patient (Case #1) treated in Johannesburg, South Africa, 1975. This slide reveals findings indicative of acute tubular necrosis (ATN), and glomerular fibrin thromboses resulting from a Marburg disease infection. Both changes occur not only with the Marburg virus, but other viral hemorrhagic fevers as well. A Centers for Disease Control and Prevention (CDC) investigation occurred after two travelers were hospitalized with Marburg disease in Johannesburg. One of the travelers, referred to as Case #1, came into contact with an unknown vector while traveling through Zimbabwe, formerly Rhodesia. Case #1 then passed the Marburg virus to his traveling companion, referred to as Case #2, and a treatment nurse, Case #3.