This photomicrograph of a human skin biopsy specimen, harvested from a patient with Kaposi’s sarcoma. Of importance is the normal appearance of the most superficial epidermal layer on the far left, which was overlying the dermal layer, which contained a cellular infiltrate, and a proliferation of vascular elements. Kaposi sarcoma, is a malignant tumor of the lymphatic endothelium caused by the human herpesvirus 8 (HHV8), also referred to as Kaposi’s sarcoma-associated herpesvirus (KSHV), and arises from a cancer of the lymphatic endothelial lining. It is characterized by bluish-red cutaneous nodules. Kaposi’s sarcoma is thought of as an opportunistic infection, affecting patients whose immune systems have been compromised, as in the case of patients with HIV/AIDS.