This 1969 image depicts the face of a 17-year-old woman, 14-days after she’d received a smallpox vaccination. You’ll note the presence of a maculopapular rash around her mouth, known as eczema vaccinatum. This patient had begun treatment with vaccinia immune globulin (VIG), and was 3-days into this treatment, when this photograph was captured. VIG is a product that treats certain serious reactions to the smallpox vaccine. VIG is an immune globulin made from the blood of people, who have gotten the smallpox vaccine more than once, usually many times. See PHIL 16107, for a view of this rash, 8-days post-vaccination, and 3307 for a view of the residual scarring around the patient’s mouth, 7-months after this reaction.