In 2014, the John F. Kennedy International Airport conducted a full-scale mass casualty incident exercise. Our Preparedness and Policy Coordination Team worked with CDC’s New York Quarantine Station, to provide airport partners, an opportunity to evaluate current response concepts and capabilities, to react to an arriving quarantinable disease event. The exercise focused on resource coordination, critical decisions, notifications, and integration of local and federal assets needed to save lives, and protect public health and safety. The NY Quarantine Station included injects into the exercise, where as per federal regulations, before the mass casualty incident occurred, an aircraft pilot called Air Traffic Control stating a sick traveler was onboard. First responders were informed to be on the lookout for a survivor with specific symptoms. Here, a CDC quarantine public health officer, worked with EMS responders to assess the health of the “survivor”.