- The onset of fever in the case of smallpox takes place 2 - 4 days before the onset of the maculopapular rash, while in the case of chickenpox, the onset of the fever takes place at the same time as the onset of the rash.
- The appearance, and development of the rash in the case of smallpox is slow in its development, and the crop of papules all develop in a single stage, while in the case of chickenpox, the pocks develop rapidly, and take place in several stages.
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