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ID#:17270
Description:At the component level, this diagram illustrates two different direct hemagglutination reactions, a positive viral hemagglutination assay reaction (above), and a negative viral hemagglutination assay (HA) reaction (below). The former involves a hemagglutinating virus, while the latter involves the implementation of a non-hemagglutinating virus, and how each interacts “directly” with red blood cells.
Using this “direct” agglutination test, the agglutinating antibodies on the surface of the viral particles, or virions, react directly with antigens on the surface of the erythrocytes, or RBCs, forming a “lacey” pattern, or visible clumps of particles seen accumulating in the bottom of the test tube or well, as seen in the top reaction. A negative reaction, as seen on the bottom, reveals that there are no surface antigens present on the RBCs, which would bond to the virions, thereby, inducing an agglutination reaction, hence no hemagglutination occurs.
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Content Providers(s):CDC/ Dr. Frances Forrester
Creation Date:1975
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Copyright Restrictions:None - This image is in the public domain and thus free of any copyright restrictions. As a matter of courtesy we request that the content provider be credited and notified in any public or private usage of this image.

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