ID#: 17270
At the component level, this diagram illustrates two different direct hemagglutination reactions, a positive viral hemagglutination assay (HA) reaction (above), and a negative viral HA reaction. The former involves a hemagglutinating virus, while the latter involves the implementation of a non-hemagglutinating virus, and how each interacts directly with red blood cells. Using this direct agglutination test, the agglutinating antibodies on the surface of the viral particles, react directly with antigens on the surface of the erythrocytes (RBCs), forming a lacey pattern, or visible clumps of particles, that can be seen accumulating in the bottom of the test tube, or well, as seen in the top reaction. A negative reaction, as seen on the bottom, reveals that there are no surface antigens present on the RBCs, which would bond to the virions, thereby, inducing an agglutination reaction, hence no hemagglutination occurs.
High Resolution: Click here for hi-resolution image (24.15 MB)
Content Provider(s): CDC/ Dr. Frances Forrester
Creation Date: 1975
Photo Credit:
CDC Organization
Skip Navigation Links.

Skip Navigation Links.
Copyright Restrictions: None - This image is in the public domain and thus free of any copyright restrictions.