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Description:This illustration depicts what takes place during a neutralization reaction test with viruses, which is used to determine the presence of an antigen-antibody complex within a serum sample, and whether or not, when the serum sample is used as an inoculum, there is a subsequent cytopathic affect.
In the top half of the diagram, the viral organisms have combined with a specific antibody present in the serum sample, thereby, rendering the viruses unable to deliver their toxic effects to a potential host, which in this case is a rodent recipient of the virus-serum mixture. You can see that there is no ensuing cytopathic effect whent the rodent is inoculated with this serum mixture.

In the lower half of the diagram, you’ll note that the same test yields a cytopathic effect when another serum sample containing no specific antibodies is added to the virus. In this case, no virus-antibody complex is formed, and the virus remains free to deliver its cytopathic effect when the host is inoculated with this mixture.

High Resolution: Click here for hi-resolution image (18.48 MB)
Content Providers(s):CDC/ Dr. Francis Forrester
Creation Date:1974
Photo Credit:
CDC Organization
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Copyright Restrictions:None - This image is in the public domain and thus free of any copyright restrictions. As a matter of courtesy we request that the content provider be credited and notified in any public or private usage of this image.