|Description:||This image depicts the lower extremities of a young patient revealing bullous erythematous lesions due to a condition known as epidermolysis bullosa (EB). In the foreground, the left lateral thigh, lower leg and foot display lesions, and in the background the right medial thigh exhibits a lesion.|
EB is a group of blistering skin conditions. The skin is so fragile in people with EB that even minor rubbing may cause blistering. At times, the person with EB may not be aware of rubbing or injuring the skin even though blisters develop. In severe EB, blisters are not confined to the outer skin. They may develop inside the body, in such places as the linings of the mouth, esophagus, stomach, intestines, upper airway, bladder, and genitals.
Most people with EB have inherited the condition through faulty genes they receive from one or both parents. Genes are located in the body’s cells and determine inherited traits passed from parent to child. They also govern every bodily function, such as the formation of proteins in the skin. More than 10 genes are known to underlie the different forms of EB. Genes are located on chromosomes, which are structures in each cell’s nucleus.