This 1962 photograph depicted a 70 year-old Cardiff, Wales female, who’d received a smallpox vaccination, and subsequently developed a severe reaction to the vaccine known as vaccinia necrosum. This woman was also a chronic lymphocytic leukemia patient. See PHIL 14255, for another view of this patient's arm. Note the profusion of vaccinial vesicles at the advancing margin. This patient had received this vaccination, as a treatment for an indolent oral herpes simplex ulcer (see PHIL 14252), which proved to have been ineffective, and resulted in her development of this severe form of progressive vaccinia.