Under a high magnification of 320X, this hematoxylin-eosin-stained (H&E) photomicrograph depicts the cytoarchitectural changes found in a liver tissue specimen extracted from an “atypical” viral hepatitis patient. This particular view details a region of hepatic acidophilic necrosis, within which were a number of nearly-mature Councilman bodies. There was also some extravasation of blood into the sinusoidal capillaries within this necrotic region. When viral hepatitis is categorized as being of the atypical type, it usually means that there is an accompanying infection such as yellow fever, or malaria. Though in this particular case, any concomitant infection was unidentified.
From the booklet entitled, ”Yellow Fever: Positive and Differential Histopathology Diagnosis”, PHIL images 13001 through 13043 illustrate the findings encountered when performing a differential diagnoses comparing characteristics of liver cytoarchitecture in cases of yellow fever with viral hepatitis, Lassa fever, Marburg virus, Ebola virus, Dengue hemorrhagic fever, Congo-Crimean hemorrhagic fever, Rift Valley fever, and malnutrition.