Under a high magnification of 400X, this hematoxylin-eosin-stained (H&E) photomicrograph depicts the cytoarchitectural changes found in a liver tissue specimen extracted from a yellow fever patient using a needle biopsy method. In this particular view, you’ll note a maturing Councilman body that is surrounded by hepatocytes, as well as accompanying fatty changes indicated by the presence of microvacuoles due to yellow fever, and macrovacuolar changes due to the impact of malnutrition. Also present, due to an accompanying malarial infection, are hemosiderin-filled Kuppfer cells. See PHIL 2176, and 8239, depicting TEMs of the yellow fever virus.
From the booklet entitled, ”Yellow Fever: Positive and Differential Histopathology Diagnosis”, PHIL images 13001 through 13043 illustrate the findings encountered when performing a differential diagnoses comparing characteristics of liver cytoarchitecture in cases of yellow fever with viral hepatitis, Lassa fever, Marburg virus, Ebola virus, Dengue hemorrhagic fever, Congo-Crimean hemorrhagic fever, Rift Valley fever, and malnutrition.