|Description:||This 1965 image depicted an enlarged view of a single cutaneous lesion located on the right lateral wrist region of the same patient seen in PHIL 12180. The patient, a 20 year old male displayed numerous cutaneous arsenical keratoses, and this proved to be a very early lesion. From his infancy, this individual suffered with asthma, and approximately 10 years prior to this photograph, he’d been treated for this condition with a medication containing arsenic. These arsenical keratotic lesions had formed over the last two years. Note that in the background, one can see the supraumbilical squamous cell carcinoma in situ lesion seen in PHIL 12181.|
Arsenic has been known to be a cutaneous carcinogen, and has shown to cause what is known as Bowen disease, which is squamous cell carcinoma in situ, as well more severe, i.e., invasive, forms of squamous, and basal cell carcinoma. As a cause of hyperpigmented, hyperkeratotic cutaneous lesions known here, as arsenical keratoses, these lesions are the most common skin lesion indicative of long-term arsenic exposure.