ID#: 10159
Caption:
Under a magnification of 400X, this photomicrograph depicted details displayed by a specimen consisting of lung tissue from a Knoxville patient with a fatal pneumonia due to Legionnaires’ disease. A fluorescent antibody stain was implemented, consisting of the Knoxville strain conjugate, i.e., an antibody with an affinity to L. pneumophila bacterial antigen, and a fluorochrome, which is a fluorescent dye, e.g. fluorescein isothiocyanate. The presence of the Legionella bacteria was evidenced, when the antibody-dye complex became bound to serum antigen circulating throughout the patient, due to the presence of the pathogen. Subsequently, when the antibody conjugate-antigen complex was exposed to light, it produced a fluorescent effect.
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Content Provider(s): CDC/ Dr. William Cherry
Creation Date: 1978
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Copyright Restrictions: None - This image is in the public domain and thus free of any copyright restrictions.