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Description:This 1976 transmission electron microscopic (TEM) image depicted a peritoneal mesothelial cell from a mouse that had been experimentally infected intraperitoneally with Orientia tsutsugamushi rickettsial micro-organisms. Captured here in this TEM was the initiation of the process of phagocytosis being carried out on one of the O. tsutsugamushi micro-organisms.
In humans, O. tsutsugamushi attacks endothelial cells resulting in vasculitis. The clinical manifestations are characterized by papular rash, headache, fever, chills, and an eschar at the site of the chigger bite, i.e. the mode of human inoculation. The disease can be tested serologically by the detection of significant increases of IFA (indirect fluorescent antibody) in paired serum drawn at the onset of disease, and 2 - 3 weeks later. Traditionally, isolation of the rickettsia from the blood by inoculation intraperitoneally into white mice is the definite confirmatory method.
High Resolution: Click here for hi-resolution image (5.82 MB)
Content Providers(s):CDC/ Dr. Ed Ewing
Creation Date:1976
Photo Credit:
CDC Organization
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Copyright Restrictions:None - This image is in the public domain and thus free of any copyright restrictions. As a matter of courtesy we request that the content provider be credited and notified in any public or private usage of this image.