This 1969 image depicts the face of a 17-year-old woman, 7-months after she’d received a smallpox vaccination. You’ll note the presence of residual scarring of her face left behind after her reaction to her smallpox vaccination. This patient was treated with vaccinia immune globulin (VIG) in order to counteract the onset of her maculopapular rash, seen in PHIL 16107, 8-days post-vaccination, and 3306, 14-days post vaccination. VIG is a product that treats certain serious reactions to the smallpox vaccine. VIG is an immune globulin made from the blood of people, who have gotten the smallpox vaccine more than once, usually many times.