CDC uses “Next Generation Sequencing” (NGS) methodologies that provide a tremendous amount of detail about each influenza genome. NGS techniques represent various high-throughput DNA sequencing strategies, whereby, millions to billions of DNA strands are sequenced in a highly parallel manner, dramatically improving throughput to understand sample complexity. This level of detail benefits decision-making with regard to vaccine composition, because it can help identify emerging changes in circulating flu viruses much earlier than before.