|Description:||This image depicts the penis of a male with its foreskin retracted, revealing a suppurative lesion involving the glans and prepuce. The cause of this lesion had been diagnosed as a case of penile Donovanosis, also known as granuloma inguinale, a disease caused by the Gram-negative bacterium, Klebsiella granulomatis, formerly known as Calymmatobacterium granulomatis, and even earlier Donovania granulomatis.|
Clinically, the disease is commonly characterized as painless, slowly progressive ulcerative lesions on the genitals or perineum without regional lymphadenopathy; subcutaneous granulomas (pseudobuboes) might also occur. The lesions are highly vascular (i.e., beefy red appearance) and bleed easily on contact. The clinical presentation also can include hypertrophic, necrotic, or sclerotic variants. Extragenital infection can occur with extension of infection to the pelvis, or it can disseminate to intra-abdominal organs, bones, or the mouth. The lesions also can develop secondary bacterial infection and can coexist with other sexually transmitted pathogens.