|Description:||This diagram illustrates the cyclical method that the arboviral California serogroup viruses (CALV) adopt in order to replicate using predominantly, the Aedes spp. mosquitoes to transmit the viruses to small woodland vertebrates, in order to amplify the viral populations prior to infecting human beings through the bite of a virus-carrying Aedes sp. mosquito.|
California serogroup viruses cause what is know as neuroinvasive disease. Neuroinvasive disease includes cases reported as encephalitis, meningoencephalitis, and meningitis. Most reported cases of California serogroup virus neuroinvasive disease are due to La Crosse encephalitis virus.
Many arboviruses cause neuroinvasive disease such as aseptic meningitis, encephalitis, or acute flaccid paralysis (AFP). These illnesses are usually characterized by the acute onset of fever with stiff neck, altered mental status, seizures, limb weakness, cerebrospinal fluid (CSF) pleocytosis, or abnormal neuroimaging. AFP may result from anterior ("polio") myelitis, peripheral neuritis, or post-infectious peripheral demyelinating neuropathy (i.e., Guillain-Barré syndrome). Less common neurological manifestations, such as cranial nerve palsies, also occur.