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Description:This diagram illustrates the cyclical method that the arboviral California serogroup viruses (CALV) adopt in order to replicate using predominantly, the Aedes spp. mosquitoes to transmit the viruses to small woodland vertebrates, in order to amplify the viral populations prior to infecting human beings through the bite of a virus-carrying Aedes sp. mosquito.

California serogroup viruses cause what is know as neuroinvasive disease. Neuroinvasive disease includes cases reported as encephalitis, meningoencephalitis, and meningitis. Most reported cases of California serogroup virus neuroinvasive disease are due to La Crosse encephalitis virus.
Neuroinvasive disease:

Many arboviruses cause neuroinvasive disease such as aseptic meningitis, encephalitis, or acute flaccid paralysis (AFP). These illnesses are usually characterized by the acute onset of fever with stiff neck, altered mental status, seizures, limb weakness, cerebrospinal fluid (CSF) pleocytosis, or abnormal neuroimaging. AFP may result from anterior ("polio") myelitis, peripheral neuritis, or post-infectious peripheral demyelinating neuropathy (i.e., Guillain-Barré syndrome). Less common neurological manifestations, such as cranial nerve palsies, also occur.

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Content Providers(s):CDC
Creation Date:1969
Photo Credit:
Links:CDC - National Center for Emerging and Zoonotic Infectious Diseases (NCEZID); Division of Vector-Borne Diseases (DVBD); La Crosse Encephalitis: California Serogroup Virus Neuroinvasive Disease
CDC - Arboviral Diseases, Neuroinvasive and Non-Neuroinvasive: 2011 Case Definition
CDC Organization
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Copyright Restrictions:None - This image is in the public domain and thus free of any copyright restrictions. As a matter of courtesy we request that the content provider be credited and notified in any public or private usage of this image.