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Description:Under a magnification of 1000X, this hematoxylin-eosin (H&E) stained photomicrograph reveals some of the ultrastructural histopathologic changes found in a vaginal tissue biopsy specimen indicative of adenocarcinoma of the vagina. In this case, involving a teenage girl, it was believed that the onset of this cancer may have been due to the fact that the patient’s mother had taken diethylstilbestrol (DES) while pregnant, as a treatment to avoid a possible spontaneous abortion.
DES Daughters are at increased risk for a wide range of abnormalities involving the Müllerian-derived portion of the genital tract, including clear cell adenocarcinoma (CCA) of the vagina and cervix, genital malformations, infertility and adverse pregnancy outcomes. In addition, DES Daughters may be at increased risk for development of cervical dysplasia. See the link below for further information regarding the use of DES during pregnancy.
High Resolution: Click here for hi-resolution image (18.38 MB)
Content Providers(s):CDC/ A. Elizabeth Plott, C.T.(ASCP)
Creation Date:1975
Photo Credit:
Links:CDC – National Center for Chronic Disease Prevention and Health Promotion; Division of Cancer Prevention and Control; Gynecologic Cancers: Cervical Cancer
CDC –Centers of Excellence in Women’s Health (HHS); DES (diethylstilbestrol) Update: Current Information
CDC Organization
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Copyright Restrictions:None - This image is in the public domain and thus free of any copyright restrictions. As a matter of courtesy we request that the content provider be credited and notified in any public or private usage of this image.