- May be familial or sporadic
- Sporadic DN occur in 5 – 10% of the population
- 90% of malignant melanoma (MM) are diagnosed with sporadic MM, and approximately 40% of this subset, also have clinical DN
- Approximately 20% of sporadic MM arise in a DN, which is the most important precursor of MM
- DN Syndrome is defined as displaying clinically-atypical nevi along with two or more family members with MM; DN Syndrome leads to a greater than 50% risk of developing MM
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