Under a high magnification of 1000X, and using an oil immersion technique to aid visualization, this hematoxylin-eosin-stained (H&E) photomicrograph depicts the cytoarchitectural changes found in a liver tissue specimen extracted from a deceased yellow fever patient. Note the “Councilman body with some microvacuoles resulting from fatty necrosis.”. See PHIL 2176, and 8239, depicting TEMs of the yellow fever virus.
Yellow fever histopathologic diagnostic confirmation is based upon the following cytoarchitectural changes: parenchymal disorganization; midzonal necrosis; acidophilic degeneration; fatty degeneration.
From the booklet entitled, ”Yellow Fever: Positive and Differential Histopathology Diagnosis”, PHIL images 13001 through 13043 illustrate the findings encountered when performing a differential diagnoses comparing characteristics of liver cytoarchitecture in cases of yellow fever with viral hepatitis, Lassa fever, Marburg virus, Ebola virus, Dengue hemorrhagic fever, Congo-Crimean hemorrhagic fever, Rift Valley fever, and malnutrition.