Under a low magnification of only 40X, this hematoxylin-eosin-stained (H&E) photomicrograph depicts the cytoarchitectural changes found in a liver tissue specimen extracted from a deceased yellow fever patient. This particular image reveals the presence of “massive necrosis, which extends to the periportal region, where only a few hepatocytes remained.”. See PHIL 2176, and 8239, depicting TEMs of the yellow fever virus.
Yellow fever histopathologic diagnostic confirmation is based upon the following cytoarchitectural changes: parenchymal disorganization; midzonal necrosis; acidophilic degeneration; fatty degeneration.
From the booklet entitled, ”Yellow Fever: Positive and Differential Histopathology Diagnosis”, PHIL images 13001 through 13043 illustrate the findings encountered when performing a differential diagnoses comparing characteristics of liver cytoarchitecture in cases of yellow fever with viral hepatitis, Lassa fever, Marburg virus, Ebola virus, Dengue hemorrhagic fever, Congo-Crimean hemorrhagic fever, Rift Valley fever, and malnutrition.