ID#: 13006
Caption:
Under a low magnification of 100X, this hematoxylin-eosin-stained (H&E) photomicrograph depicts the cytoarchitectural changes found in a liver tissue specimen extracted from a deceased yellow fever patient. Note that only a “thin collar of hepatocytes are visible around the portal space.” There is also a “massive acidophilic necrosis” underway, as well as “numerous complete, or incomplete Councilman bodies, which are evident.”. Finally, there is a “discrete lymphocytic infiltrate” present. See PHIL 2176, and 8239, depicting TEMs of the yellow fever virus.

Yellow fever histopathologic diagnostic confirmation is based upon the following cytoarchitectural changes: parenchymal disorganization; midzonal necrosis; acidophilic degeneration; fatty degeneration.
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Content Provider(s): Dr. Yves Robin and Dr. Jean Renaudet, Arbovirus Laboratory at the Pasteur Institute in Dakar, Senegal; World Health Organization
Creation Date: 1980
Photo Credit:
Links: © Copyright Notice: World Health Organization (WHO)
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