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ID#:13006
Description:Caption:
Under a low magnification of 100X, this hematoxylin-eosin-stained (H&E) photomicrograph depicts the cytoarchitectural changes found in a liver tissue specimen extracted from a deceased yellow fever patient. Note that only a “thin collar of hepatocytes are visible around the portal space.” There is also a “massive acidophilic necrosis” underway, as well as “numerous complete, or incomplete Councilman bodies, which are evident.”. Finally, there is a “discrete lymphocytic infiltrate” present. See PHIL 2176, and 8239, depicting TEMs of the yellow fever virus.

Yellow fever histopathologic diagnostic confirmation is based upon the following cytoarchitectural changes: parenchymal disorganization; midzonal necrosis; acidophilic degeneration; fatty degeneration.
Additional Information:
From the booklet entitled, ”Yellow Fever: Positive and Differential Histopathology Diagnosis”, PHIL images 13001 through 13043 illustrate the findings encountered when performing a differential diagnoses comparing characteristics of liver cytoarchitecture in cases of yellow fever with viral hepatitis, Lassa fever, Marburg virus, Ebola virus, Dengue hemorrhagic fever, Congo-Crimean hemorrhagic fever, Rift Valley fever, and malnutrition.

High Resolution: Click here for hi-resolution image (18.27 MB)
Content Providers(s):Dr. Yves Robin and Dr. Jean Renaudet, Arbovirus Laboratory at the Pasteur Institute in Dakar, Senegal; World Health Organization
Creation Date:1980
Photo Credit:
Links:© Copyright Notice: World Health Organization (WHO)
Categories:
CDC Organization
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Copyright Restrictions:Yes - This image is copyright protected. Any public or private use of this image is subject to prevailing copyright laws.Please contact the content provider of this image for permission requests.

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