|Description:||This 1965 image depicted an enlarged view of a single cutaneous lesion located superior to the umbilicus of the same patient seen in PHIL 12180. The patient, a 20 year old male displayed numerous cutaneous arsenical keratoses. Under histologic examination, this lesion proved to be squamous cell carcinoma in situ. From his infancy, this individual suffered with asthma, and approximately 10 years prior to this photograph, he’d been treated for this condition with a medication containing arsenic. These arsenical keratotic lesions had formed over the last two years.|
Arsenic has been known to be a cutaneous carcinogen, and has shown to cause what is known as Bowen disease, which is squamous cell carcinoma in situ, as well more severe, i.e., invasive, forms of squamous, and basal cell carcinoma. As a cause of hyperpigmented, hyperkeratotic cutaneous lesions known here, as arsenical keratoses, these lesions are the most common skin lesion indicative of long-term arsenic exposure.