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Description:Under a high magnification of 8000X, this scanning electron microscopic (SEM) image revealed some of the ultrastructural morphology displayed by red blood cells (RBCs) in a blood specimen of a 6 year old male patient that has sickle cell with hereditary persistence of fetal hemoglobin (S-HPFH). In these individuals, the presence of the persistent fetal hemoglogin reduces the severity of the consequences of the sickle cell disease, thereby, reducing the degree of cellular deformity, i.e., sickling, seen in the sickled cells. See PHIL 11692 for a digitally-colorized version of this image.
Sickle cell disease is a group of inherited red blood cell disorders. Healthy red blood cells are round, and they move through small blood vessels to carry oxygen to all parts of the body. In sickle cell disease, the red blood cells become hard and sticky and look like a C-shaped farm tool called a “sickle”. The sickle cells die early, which causes a constant shortage of red blood cells. Also, when they travel through small blood vessels, they get stuck and clog the blood flow. This can cause pain and other serious problems.
High Resolution: Click here for hi-resolution image (5.49 MB)
Content Providers(s):CDC/ Sickle Cell Foundation of Georgia: Jackie George, Beverly Sinclair
Creation Date:2009
Photo Credit:Janice Haney Carr
Links:Sickle Cell Foundation of Georgia, Inc.
CDC - National Center on Birth Defects and Developmental Disabilities, Division of Blood Disorders; Sickle Cell Disease
CDC - National Center on Birth Defects and Developmental Disabilities, Division of Blood Disorders; Types of Sickle Cell Disease
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Copyright Restrictions:None - This image is in the public domain and thus free of any copyright restrictions. As a matter of courtesy we request that the content provider be credited and notified in any public or private usage of this image.