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PHIL Image 8160
 
ID#:8160
Description:This negative stained transmission electron micrograph (TEM) shows recreated 1918 influenza virions that were collected from supernatants of 1918-infected Madin-Darby Canine Kidney (MDCK) cells cultures 18 hours after infection.

To separate these virions, the MDCK cells are spun down (centrifugation), and the 1918 virus in the fluid is immediately fixed for negative staining. The solid mass in lower center contains MDCK cell debris that did not spin down during the procedure. See PHIL 11098 for a colorized version of this image.

Dr. Terrence Tumpey, one of the organization’s staff microbiologists and a member of the National Center for Infectious Diseases (NCID), recreated the 1918 influenza virus in order to identify the characteristics that made this organism such a deadly pathogen. Research efforts such as this, enables researchers to develop new vaccines and treatments for future pandemic influenza viruses.

The 1918 Spanish flu epidemic was caused by an influenza A (H1N1) virus, killing more than 500,000 people in the United States, and up to 50 million worldwide. The possible source was a newly emerged virus from a swine or an avian host of a mutated H1N1 virus. Many people died within the first few days after infection, and others died of complications later. Nearly half of those who died were young, healthy adults. Influenza A (H1N1) viruses still circulate today after being introduced again into the human population in the 1970s.

High Resolution:Right click here and select "Save Target As..." for hi-resolution image (3.78 MB)
Content Providers(s):CDC/ Dr. Terrence Tumpey
Creation Date:2005
Photo Credit:Cynthia Goldsmith
Links:
  • CDC – Information About Influenza Pandemics
    Categories:
    CDC Organization
    tree picture Organization 2004 present
    tree picture tree picture Coordinating Center for Infectious Diseases
    tree picturetree picture tree picture National Center for Infectious Diseases
    tree picturetree picturetree picture tree picture Division of Viral and Rickettsial Diseases

    MeSH
    tree picture Analytical, Diagnostic and Therapeutic Techniques and Equipment
    tree picture tree picture Diagnosis
    tree picturetree picture tree picture Diagnostic Techniques and Procedures
    tree picturetree picturetree picture tree picture Diagnostic Imaging
    tree picturetree picturetree picturetree picture tree picture Microscopy, Electron
    tree picture tree picture Investigative Techniques
    tree picturetree picture tree picture Microscopy
    tree picturetree picturetree picture tree picture Microscopy, Electron
    tree picture Organisms
    tree picture tree picture Viruses
    tree picturetree picture tree picture RNA Viruses
    tree picturetree picturetree picture tree picture Orthomyxoviridae
    tree picturetree picturetree picturetree picture tree picture Influenzavirus A
    tree picturetree picturetree picturetree picturetree picture tree picture Influenza A virus
    tree picturetree picture tree picture Vertebrate Viruses
    tree picturetree picturetree picture tree picture RNA Viruses
    tree picturetree picturetree picturetree picture tree picture Orthomyxoviridae
    tree picturetree picturetree picturetree picturetree picture tree picture Influenzavirus A
    tree picturetree picturetree picturetree picturetree picturetree picture tree picture Influenza A virus
    Copyright Restrictions:None - This image is in the public domain and thus free of any copyright restrictions. As a matter of courtesy we request that the content provider be credited and notified in any public or private usage of this image.
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