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PHIL Image 10707
 
ID#:10707
Description:This thin-section transmission electron micrograph (TEM) revealed the ultrastructural appearance of a single virus particle, or “virion”, of measles virus. The measles virus is a paramyxovirus, of the genus Morbillivirus. It is 100-200 nm in diameter, with a core of single-stranded RNA, and is closely related to the Rinderpest and canine distemper viruses. Two membrane envelope proteins are important in pathogenesis. They are the F (fusion) protein, which is responsible for fusion of virus and host cell membranes, viral penetration, and hemolysis, and the H (hemagglutinin) protein, which is responsible for adsorption of virus to cells.

There is only one antigenic type of measles virus. Although studies have documented changes in the H glycoprotein, these changes do not appear to be epidemiologically important (i.e., no change in vaccine efficacy has been observed). See PHIL 8429 for a black and white version of this image.

Prior to 1963, almost everyone got measles; it was an expected life event. Each year in the U.S. there were approximately 3 to 4 million cases and an average of 450 deaths, with epidemic cycles every 2 to 3 years. More than half the population had measles by the time they were 6 years old, and 90 % had the disease by the time they were 15. This indicates that many more cases were occurring than were being reported. However, after the vaccine became available, the number of measles cases dropped by 98 % and the epidemic cycles drastically diminished.

Measles virus is rapidly inactivated by heat, light, acidic pH, ether, and trypsin. It has a short survival time (<2 hours) in the air, or on objects and surfaces.

High Resolution:Right click here and select "Save Target As..." for hi-resolution image (28.33 MB)
Content Providers(s):CDC/ Cynthia S. Goldsmith; William Bellini, Ph.D.
Creation Date:
Photo Credit:
Links:
  • CDC – Nat. Immunization Program (NIP); Measles
    Categories:
    CDC Organization

    MeSH
    tree picture Analytical, Diagnostic and Therapeutic Techniques and Equipment
    tree picture tree picture Diagnosis
    tree picturetree picture tree picture Diagnostic Techniques and Procedures
    tree picturetree picturetree picture tree picture Diagnostic Imaging
    tree picturetree picturetree picturetree picture tree picture Microscopy, Electron
    tree picturetree picturetree picturetree picturetree picture tree picture Microscopy, Electron, Scanning
    tree picturetree picturetree picturetree picturetree picturetree picture tree picture Microscopy, Electron, Scanning Transmission
    tree picture tree picture Investigative Techniques
    tree picturetree picture tree picture Microscopy
    tree picturetree picturetree picture tree picture Microscopy, Electron
    tree picturetree picturetree picturetree picture tree picture Microscopy, Electron, Scanning
    tree picturetree picturetree picturetree picturetree picture tree picture Microscopy, Electron, Scanning Transmission
    tree picturetree picturetree picture tree picture Photomicrography
    tree picture Diseases
    tree picture tree picture Virus Diseases
    tree picturetree picture tree picture RNA Virus Infections
    tree picturetree picturetree picture tree picture Mononegavirales Infections
    tree picturetree picturetree picturetree picture tree picture Paramyxoviridae Infections
    tree picturetree picturetree picturetree picturetree picture tree picture Morbillivirus Infections
    tree picturetree picturetree picturetree picturetree picturetree picture tree picture Measles
    tree picture Organisms
    tree picture tree picture Viruses
    tree picturetree picture tree picture RNA Viruses
    tree picturetree picturetree picture tree picture Mononegavirales
    tree picturetree picturetree picturetree picture tree picture Paramyxoviridae
    tree picturetree picturetree picturetree picturetree picture tree picture Paramyxovirinae
    tree picturetree picturetree picturetree picturetree picturetree picture tree picture Morbillivirus
    tree picturetree picturetree picturetree picturetree picturetree picturetree picture tree picture Measles virus
    tree picturetree picture tree picture Vertebrate Viruses
    tree picturetree picturetree picture tree picture RNA Viruses
    tree picturetree picturetree picturetree picture tree picture Mononegavirales
    tree picturetree picturetree picturetree picturetree picture tree picture Paramyxoviridae
    tree picturetree picturetree picturetree picturetree picturetree picture tree picture Paramyxovirinae
    tree picturetree picturetree picturetree picturetree picturetree picturetree picture tree picture Morbillivirus
    tree picturetree picturetree picturetree picturetree picturetree picturetree picturetree picture tree picture Measles virus
    Copyright Restrictions:None - This image is in the public domain and thus free of any copyright restrictions. As a matter of courtesy we request that the content provider be credited and notified in any public or private usage of this image.
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